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Displaying 61 - 80 of 206 records Index
Oral Engaging with the next generation of ‘Cochranites’ through an international web-based community
2013 Québec City
Millward, Burton
Background: The UKCC seeks to improve health by promoting the production, understanding and use of high quality research evidence by patients, healthcare professionals and those who organise and fund our healthcare services. Students in all healthcare disciplines are the practitioners of tomorrow…
Oral Enhancing the acceptance and implementation of GRADE summary of findings tables for evidence about diagnostic tests
2013 Québec City
Mustafa, Wiercioch, Brozek, Lelgemann, Buehler, Garg, Bossuyt, Schünemann
Background: The Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group developed Summary tables adapted to summarise and present evidence from diagnostic test accuracy (DTA) systematic reviews.
Objective: To develop guidance on what information to include in…
Oral Enhancing the efficiency of the systematic review process for evidence-based medicine
2013 Québec City
Crawford, Jonas
Background: Systematic reviews are widely recognized as the best means of synthesizing clinical research; however traditional approaches can be costly and time-consuming and are often subject to selection and judgment bias. It can be difficult to interpret the results of a systematic review in…
Oral Enhancing the efficiency of the systematic review process for evidence-based medicine
2013 Québec City
Crawford, Jonas
Background: Systematic reviews are widely recognized as the best means of synthesizing clinical research; however traditional approaches can be costly and time-consuming and are often subject to selection and judgment bias. It can be difficult to interpret the results of a systematic review in…
Oral Enhancing transparency in reporting the synthesis of qualitative research: the ENTREQ statement—discussion and debate
2013 Québec City
McInnes, Tong, Flemming, Oliver, Craig
Background: The ENTREQ statement was developed to assist reviewers report the stages most commonly associated with the synthesis of qualitative health research. It consists of 21 items, has undergone some pilot testing, been published in a peer-reviewed journal and posted on the EQUATOR web-site…
Oral Epidemiology and publication of discontinued randomized trials—the DISCO study
2013 Québec City
Kasenda, von Elm, You, Blümle, Tomonaga, Saccilotto, Amstutz, Bengough, Meerpohl, Stegert, Briel
Background: Discontinuation of randomized clinical trials (RCTs) has ethical implications: Participants consent on the premise of contributing to new medical knowledge, non-publication of discontinued RCTs compromises systematic reviews, and precious resources are wasted. Little is known about the…
Oral Epistemonikos: a comprehensive, systematic, collaborative and multilingual database for evidence-based health care
2013 Québec City
Rada, Capurro, Rivera, Peña, Claro, Soto, Neumann, Pérez
Background: Epistemonikos (www.epistemonikos.org) is a user-friendly, multilingual, collaborative database of evidence. One unique feature of this database is that connects different types of evidence and allows to compare different systematic reviews addressing a similar question.
Methods:…
Oral Epistemonikos: a comprehensive, systematic, collaborative and multilingual database for evidence-based health care
2013 Québec City
Rada, Capurro, Rivera, Peña, Claro, Soto, Neumann, Pérez
Background: Epistemonikos (www.epistemonikos.org) is a user-friendly, multilingual, collaborative database of evidence. One unique feature of this database is that connects different types of evidence and allows to compare different systematic reviews addressing a similar question.
Methods:…
Oral Estimating a test’s accuracy using tailored meta-analysis—the potential of setting-specific data in aiding study selection
2013 Québec City
Willis, Hyde
Background: The decision on whether a diagnostic test accuracy study is applicable to practice is largely a qualitative process. Consequently, the summary estimates provided by meta-analysis may be, in some cases, completely inaccurate for a particular setting.
Objectives: To develop a new…
Oral Ethics of randomised controlled trials challenged: the selective cross-over in trials assessing efficacy of therapies for breast cancer patients
2013 Québec City
Balduzzi, Miglio, Petracci, Guarneri, Moja, D’Amico
Background: Selective cross-over (SCO), defined as the opportunity given to patients in a randomised controlled trial (RCT) to switch to the experimental arm, is an increasingly common phenomenon. Although there are various reasons justifying it, the equipoise principle is challenged and problems…
Oral Evaluating the transitivity assumption when constructing network meta-analyses: lumping or splitting?
2013 Québec City
Lindsley, Cameron, Wormald, Li, Dickersin
Background: In conducting a network meta-analysis of medical interventions for open-angle glaucoma including 311 trials and 139 interventions, our first task was construction of the network. The transitivity assumption, which says that the comparative effectiveness of treatments A versus B can be…
Oral Evidence on tap: youth suicide prevention
2013 Québec City
Bennett, n/a
Objectives: We partnered with Government of Canada policy-makers through the Canadian Institutes of Health Research (CIHR) Evidence on Tap program to conduct an expedited knowledge synthesis (EKS) on youth suicide prevention. The goal was to inform a national suicide prevention strategy with…
Oral Evidence packaging to support public deliberation
2013 Québec City
Lavis, Abelson
Background: The use of deliberative dialogues to address pressing health challenges has generated a lot of interest in recent years as a promising way to engage citizens and stakeholders. Deliberative dialogues are usually informed by a pre-circulated evidence brief that mobilizes relevant research…
Oral Exploring increasing levels of complexity and reduction of uncertainty in network meta-analysis
2013 Québec City
Caldwell, Dias, Welton
Background: Network Meta-Analysis (NMA) pools direct and indirect evidence on relative treatment effects in a simultaneous analysis. NMA is increasingly applied in the evaluation of multiple competing treatments, however it requires substantially more systematic review resources. One frequently…
Oral Exploring mechanisms of publication bias in systematic reviews of diagnostic test accuracy
2013 Québec City
van Enst, Naaktgeboren, Ochodo, Leeflang, Reitsma, de Groot, Bossuyt, Moons, Scholten, Hooft
Background: Selective publication can seriously threaten the validity of the results of a systematic review. For intervention studies various mechanisms of selective publication have been identified. The mechanisms underlying selective publication of studies on diagnostic test accuracy (DTA),…
Oral Extent of publication bias in cohorts of studies approved by research ethics committees and included in trial registries
2013 Québec City
Schmucker, von Elm, Schwarzer, Schell, Blümle, Meerpohl
Background: The synthesis of published research in systematic reviews is increasingly important in providing evidence to inform clinical and health policy decision making. However, its validity is threatened if publications represent a biased selection of all studies that have been conducted (…
Oral Formulating recommendations to increase appropriateness and efficiency in healthcare: the MAPAC initiative
2013 Québec City
Solá, Quintana, Urrútia, Bolibar, Gich, Puig, Balasso, Bonfill
Background: Appropriateness in healthcare is not always warranted and some clinical practices do not integrate the available evidence with the resources required to implement it. For these reasons it is essential to promote initiatives that try to reduce inefficiency.
Objectives: To describe an…
Oral Future Tech: CRS
2013 Québec City
Dooley, Foxlee
Background: This abstract is proposed as one of a four-part session called ‘Future Tech’, comprising submissions from Gordon Dooley (CRS), Chris Mavergames (Web, Linked Data), and Jessica Thomas (IMS).
Objectives: To illustrate how the Cochrane Register of Studies (CRS) fits into the wider…
Oral Future Tech: Cochrane’s web presences (including The Cochrane Library)
2013 Québec City
Mavergames, Becker
Background: This abstract is proposed as one of a four-part session called ‘Future Tech’, comprising submissions fromGordon Dooley (CRS), Chris Mavergames (Web, Linked Data), and Jessica Thomas (IMS). The way we present our knowledge to end-users is very much tied to the ‘container’ of the…
Oral Future Tech: IMS
2013 Québec City
Thomas, Riis
This abstract is proposed as one of a four-part session called ‘Future Tech’, comprising submissions from Gordon Dooley (CRS), Chris Mavergames (Web, Linked Data), and Jessica Thomas (IMS). The IMS team has been working on software to support the writing of Cochrane Reviews almost as long as the…