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Displaying 1681 - 1700 of 3551 records Index
Oral Making the GRADE approach for network meta-analysis more efficient
2017 Cape Town [Global Evidence Summit]
Brignardello-Petersen, Bonner, Alexander, Guyatt
Background: Assessing the certainty of the evidence from a systematic review is a crucial task to draw appropriate conclusions. In systematic reviews that conduct network-meta analysis (NMA), this task can be perceived as onerous and time-consuming.
Objectives: To describe the conceptual…
Oral Making the case for investing in public health: Return on investment
2017 Cape Town [Global Evidence Summit]
Owen, Pennington, Nolan
Background:The economic consequences of premature death and preventable illness are considerable.
The National Institute for Health and Care Excellence (NICE) in England has developed return on investment (ROI) tools to enable the determination of the cost impact and ROI of public-health…
Oral Management of Vascular Anomalies and Hip Dysplasia in Children According to International Recommendations
2017 Cape Town [Global Evidence Summit]
Melnyk, Lishchyshyna
Background: Management of different diseases in children is often complicated due to the lack of evidence concerning certain medical interventions in children, especially innovative ones.
Objectives: To develop up-to-date, evidence-based clinical guidelines and protocols of medical care for the…
Oral Meta-ethnography reporting Guidance (eMERGe)
2017 Cape Town [Global Evidence Summit]
Noyes, Uny, Cunningham
Background: Evidence-based policy and practice require robust evidence syntheses which can further our understanding of people’s experiences (e.g. regarding healthcare). Meta-ethnography is a 7-phase qualitative evidence synthesis method, developed by Noblit and Hare (1988). The approach, although…
Oral MetaPROM – Enhancing the interpretation of Meta-analyses of Patient-Reported Outcome Measures through a Microsoft Excel-based statistical software program
2017 Cape Town [Global Evidence Summit]
Devji, Guyatt, Svendrovski, da Costa, Johnston
Background: Interpretation of the magnitude of treatment effects for most continuous outcomes and, particularly for patient-reported outcome measures (PROMs), presents challenges. Having decided which PROMs to include in a meta-analysis, review authors must ensure the results they present are…
Oral Minimally important difference estimates and assessment of their credibility for patient-reported outcomes in adults: A systematic survey
2017 Cape Town [Global Evidence Summit]
Carrasco-Labra, Devji, Lytvyn, Brignardello-Petersen, Prasad, Devasenapathy, Zeraatkar, Foroutan, Pardo-Hernandez, Vernooij, Jin, Ross, Quach, Schandelmaier, Panepinto, Bhatt, Qasim, Phillips, Furukawa, Patrick, Schünemann, Johnston, Ebrahim, Nesrallah, Guyatt
Background:Patient-reported outcomes (PROs) capture patients’ perspectives on treatment benefits and harms. Understanding PROs requires determining a level of improvement or deterioration that patients consider important. The most common reference point for interpretation of PROs is the minimal…
Oral More knowledge is required. Stakeholder engagement and ownership in systematic reviews
2017 Cape Town [Global Evidence Summit]
Miljand, Zetterberg, Johansson
Background: Systematic reviews on environmental issues are still not commonly used by decision makers. One important reason is the lack of ownership of the results. The Swedish centre of the Collaboration for Environmental Evidence (CEE) network, the Mistra Council for Evidence-based Environmental…
Oral More than 30 nutritional studies assessed with ROBINS-I – lessons learned
2017 Cape Town [Global Evidence Summit]
Toews, Küllenberg de Gaudry, Lohner
Background: The health effects and safety of non-nutritive sweeteners were investigated through various studies, with different study designs. ROBINS-I is proposed as a tool for quality assessment of non-randomised studies (non-RCTs).
Objectives: To assess the quality of non-RCTs with ROBINS-I…
Oral Network meta-analysis of complex interventions: accounting for component effects and control group risk
2017 Cape Town [Global Evidence Summit]
Freeman, Scott, Powell, Johnston, Sutton, Cooper
Background: In many medical areas treatment interventions consist of multiple components. In 2009 Welton et al. (1) proposed 4 increasingly complex network meta-analysis models for assessing component effects of complex interventions. The additive-effects model allows a separate effect for each…
Oral Next Generation Evidence System for Maternal and Child Health Evidence: A report on the Cochrane-Gates Foundation project
2017 Cape Town [Global Evidence Summit]
Beecher, Mavergames, Becker, Noel-Storr, Ali, Bridges, Friesen, Hampson, Jurado, Ovelman, Thomas, Weiss, Woods
Background: In September 2016 Cochrane received a grant from the Bill and Melinda Gates Foundation to accelerate our development of a 'next generation evidence system' in the areas of maternal and child health in support of the Gates Foundation’s ‘Healthy Birth Growth and Development…
Oral Novel approaches to conducting overviews of reviews: Lessons from four overviews of health systems interventions
2017 Cape Town [Global Evidence Summit]
Lewin, Oxman, Ciapponi, Herrera, Opiyo, Pantoja, Paulsen, Rada, Wiysonge
Background: Overviews of the findings of systematic reviews of health systems interventions can help policy makers and other stakeholders to identify strategies for strengthening health systems. Methods for conducting such overviews are still evolving.
Objectives: 1) To examine the strengths and…
Oral Obtaining absolute effect estimates to facilitate shared decision making in the context of multiple-treatment comparisons
2017 Cape Town [Global Evidence Summit]
Spineli, Brignardello-Petersen, Heen, Achille, Brandt, Guyatt, Vandvik, Agoritsas
Background: When engaging in shared decision making (SDM) clinicians and patients need to discuss the benefits and harms of available treatment options. To avoid framing bias, decision aids should present the evidence as absolute estimates of effect, but there is no established methodology to…
Oral Old guidelines, the SIGN decision to remove guidelines at 10 years
2017 Cape Town [Global Evidence Summit]
Kinsella, James
Background: Guideline development is time consuming and costly. Once published, guidelines may become rapidly outdated. SIGN has adopted a variety of approaches to ensuring that guidelines remain up to date and relevant. Despite this, very old guidelines remain a concern because the content could…
Oral Optimising search filters for active literature surveillance: a concordance study
2017 Cape Town [Global Evidence Summit]
Alper, Hertzman-Miller, Iorio
Background: A major challenge in keeping clinical guidelines and structured recommendations current is to identify new, relevant evidence in a resource-efficient way. Prior research found that sensitivity (minimising the number of missed relevant references) or efficiency (low number needed to read…
Oral Outcome choice and potential loss of valuable information - an example from a Cochrane Eyes and Vision systematic review
2017 Cape Town [Global Evidence Summit]
Clearfield, Money, Saldanha, Chuck, Lindsley
Background: Outcomes selected for systematic reviews (SRs) should address clinical uncertainties to help make treatment decisions. However, when reviewers select outcomes by specifying the outcome’s 5 elements (domain, measurement, method of aggregation, metric, and time point) these may not match…
Oral Overlapping of trials and systematic reviews between LILACS and PubMed
2017 Cape Town [Global Evidence Summit]
Comandé, Bardach
Background: The tevel of overlapping of trials and systematic reviews (SRs) between LILACS and PubMed is uncertain.
Objectives: To analyse the level of overlapping of trials and SRs published in the last 10 years in LILACS and PubMed.
Methods: We performed a search in January 2017 on PubMed…
Oral PICO annotation: harnessing crowds and experts in making health evidence more discoverable and re-usable
2017 Cape Town [Global Evidence Summit]
Beecher, Mavergames, Becker, Wisniewski, Noel-Storr
Background: As part of the Cochrane Linked data project, we are annotating all Cochrane systematic reviews. Phase I, which ends in March 2017, involves annotating child-health reviews. The reviews are being annotated at two levels: review level (i.e. the question) and included study level (…
Oral PROBAST – A risk-of-bias tool for prediction-modelling studies
2017 Cape Town [Global Evidence Summit]
Wolff, Moons, Riley, Whiting, Westwood, Collins, Reitsma, Kleijnen, Mallett
Background: Quality assessment of included studies is a crucial step in any systematic review (SR). Review and synthesis of prediction-modelling studies is an evolving area and a tool facilitating quality assessment for prognostic and diagnostic prediction-modelling studies is needed.…
Oral Patient-relevant context factors in guidelines
2017 Cape Town [Global Evidence Summit]
Höfer, Droste, Mischke
Background: Patient-relevant context factors are of crucial importance in the care of 'real' patients. Guideline groups thus face the challenge of developing patient-centred, not disease-centred, guidelines. In this context, the consideration of patient-relevant context factors is crucial…
Oral Plotting guidelines, tools and initiatives on the quality cycle of 30 subjects to improve care and co-operation
2017 Cape Town [Global Evidence Summit]
Hoogervorst-Schilp, van der Zwaluw, Dreesens
Background: As part of a large, nationwide programme to reduce healthcare costs and improve quality of healthcare, the so-called quality cycles of 30 subjects were drawn up. The cycles plotted tools and initiatives in 3 steps: describing good care; implementation; and measurement/evaluation. For…