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Oral A method for the rapid assessment of high-cost cancer drug indications in a hospital setting
González-Browne, Carreño-Leiton, Muñoz-Montecinos, Maza, Lahoz, Ferrer-Rosende, Nájera-De Ferrari , Quirland-Lazo
Background:
Hospitals are usually the entry point of new technologies. Facing the challenge posed by the growing costs of cancer drugs, there is a need for healthcare providers to articulate systematic and timely formulary decision-making processes considering not only the efficacy and safety of…
Oral From Evidence to Action: Implementing Cochrane Systematic Reviews Into Clinical Practice
Koster, Henry, Mohan, Whittaker
Background:
One of the tenets of Cochrane’s knowledge translation strategy is to encourage policy makers and healthcare managers to integrate Cochrane evidence into clinical practice. Cochrane reviews are among the most valuable, high-quality sources of evidence for improving quality and care…
Poster Building Partnerships Across the Systematic Review Community in the United States: Efforts by the AHRQ EPC Program
Fiordalisi, Kuhn, Holmer, Helfand, Chang, Umscheid
Background: The Scientific Resource Center (SRC) supports the Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Center (EPC) Program in convening meetings to build partnerships across the evidence-synthesis community. We explore a range of meeting formats to encourage…
Oral Working together to prioritise and synthesise evidence about promising alternative models of healthcare delivery for a more sustainable health system
O'Connor, Putrik, Wallis, Grobler, Jessup, Glasziou, Karnon, Buchbinder
Background:
Healthcare expenditure is growing at an unsustainable rate in developed countries. A recent scoping review identified several alternative healthcare delivery models with the potential to improve health system sustainability.
Objectives:
To (1) obtain input and consensus from an…
Poster The Library of Guidance for Health Scientists (LIGHTS) - introduction and outlook
Hirt, Schönenberger, Ewald, Lawson, Papola, Rohner, Suter, Lin, Germini, Zeng, Shahabinezhad, Chowdhury, Gao, Bhattacharjee, Lima, Marusic, Buljan, Agarval, Guyatt, Briel, Schandelmaier
Background: Substandard methods (e.g., irrelevant outcomes, ignoring missing data, flawed subgroup analyses) often limit the value of health research. Not seldom, corresponding methods guidance has been available for years or decades, suggesting a serious problem with the dissemination and…
Oral Did randomized trials evaluating pharmacological treatments for non-severe COVID-19 prioritize patient-important outcomes in their results?
Bravo-Soto, Montalva-Romero, Brignardello-Petersen
Background:
Clinical Practice Guidelines (CPG) played a key role during the COVID-19 pandemic. CPGs oriented decision-making in a period of high information requirements and massive research generation. One of the fundamental steps in the development of CPGs is the prioritization of the outcomes…
Poster Rapid evidence identification in reviews of post-COVID syndrome: inclusion of preprint sources and timeliness of review completion
Misso, Green, Garg, Kisomi
Background:
The COVID-19 pandemic resulted in substantial morbidity and mortality on a global scale. Subsequent to initial infection, the impact of post-acute sequelae SARS-CoV-2 infection (PASC) has become an increasing health concern. Prevalence of PASC has been estimated at 48% of COVID-19…
Poster Addressing racial health inequity: systematic review of systematic reviews
Welch, Viswanathan, Dewaidar, Rizvi, Terhune, Duque, Francis, Riddle, Heyn, Pizarro
Background: Racialized populations are affected by the sociopolitical and historical context in which they live. For example, African American and Black people face persistent discrimination and exclusion in the United States. Reducing racism and its negative consequences is a key global priority…
Poster Evidence syntheses of the health risks of weather and climate-related exposures: A scoping review
Thomson, Metzendorf, Cumpston, Wieland, Monsef, Jones, Tong, Ebi
Background:
Climate change is affecting the global burden of climate-sensitive health outcomes. Synthesizing the growing evidence base on climate-health risks and strategies for adaptation and mitigation is vital for effective decision-making. Although the number of published climate-health…
Oral PROBAST+AI: assessing quality, risk of bias and applicability of diagnostic and prognostic prediction models based on AI or ML techniques
Moons, Kaul, Damen, Andaur Navarro, Hooft, Reitsma, Riley, Collins, van Smeden
Background:
PROBAST (Prediction model Risk Of Bias Assessment Tool) has been launched in January 2019. Since then, there has been much progress and literature on the methodology for prediction modelling in general and on the use of artificial intelligence (AI) and machine learning (ML) techniques…
Oral Are there missing randomized trials in Cochrane systematic reviews and what is their impact on the results?: A methodological study
Bravo-Soto, Montalva-Romero, Brignardello-Petersen
Background:
Owing to reproducibility, reliability and exhaustiveness, systematic reviews (SRs) are considered the best type of evidence synthesis to inform decision-making, which is why the development of SRs increases every year. Because of this, it is possible to find several SRs answering the…
Oral The Theory of Everything in Health Decision-Making: Step 2
Schünemann, Reinap, Kuchenmüller, Moja, Authors of the Ecosystem of Health Decision-Making
Background: Clinicians, the public (including patients), policymakers, payers, regulators, and science communities invest considerable amounts of resources in making decisions at various levels using systematic reviews, health technology assessments (HTA), guideline recommendations, coverage…
Poster READ-It project: catalysing influential nutrition evidence synthesis and capacity building in LMICs
Naude, Durao, Brand, Visser, Schoonees, Gordon, Volmink, Garner, Young
Introduction
The Research, Evidence and Development Initiative (READ-It), funded by UK aid through the Foreign, Commonwealth and Development Office (300342-104) provides core sustained financial support to South African institutions aimed at improving health outcomes in the poor and vulnerable in…
Poster Mentorship, Community, and Evidence Synthesis Across Borders: Experiences of Cochrane US Year 2 Mentees
Gibbs, Alade, Nyanchoka, Ashmawy , Andrenacci, Bilir, Picón-Jaimes, Badawy, Rojas, Widyaningsih, Naik, Nadobudskaya, Mekolle, Tapinova, Mohandas, O’Mahony, Duque
Background: Sustainable improvement of availability, access, and adoption of trusted health evidence for all requires intentional effort to train and engage students and early- and mid-career professionals in evidence synthesis (ES), especially those from low- and middle-income countries, non-…
Poster CONSENSYS: an instrument to support CONtextual SENsitivity in SYStematic reviews
Bengough, Sommer, Hannes
Background: Systematic reviews are considered important in answering what works, for whom and in which circumstances. They often include a section on implications for policymakers and practitioners, in which they discuss relevant options to engage with. Implementation sections are coloured by the…
Oral Towards More Scientific Meta-Analyses
Zhang, Konstantinidis, Bind, Rubin
Background:
Meta-analysis typically estimates a quantity that differs from the implicitly intended estimand; typically, standard approaches estimate the average effect of a treatment for a population of imperfect studies, rather than the true scientific effect that would be measured in a…
Oral Challenges of coordinating large-scale systematic reviews
Yogasingam, Lepine, Sullivan, Antony, Konnyu, Ivers, Grimshaw
Background: Large-scale systematic reviews are becoming more common owing to the rapid growth in publications on certain topics. They raise unique challenges for managing and coordinating the review process for which there is limited guidance. We will present the challenges we encountered and how…
Oral Understanding the health impacts of climate change: search filter development for exposure pathways
Metzendorf, Monsef , Jones , Wieland , Escobar Liquitay , Janka , Thomson
Background: Climate change is the great challenge facing humanity in the 21st century. It has a wide range of health impacts that policymakers need to act upon. High-quality evidence syntheses (ES) are vital for policymaking. Search filters—validated combinations of search terms on a specific topic…
Poster Grading of recommendations in intensive care unit guidelines: A scoping review of existing methodological approaches
Ansems, Dormann, Dahms, Steinfeld, Szafran, Breuer, Benstoem
Background:
There has been an explosion of ICU guidelines for clinicians to consider in the last decade. Often, several guidelines on one and the same clinical topic, however, appear to come to different conclusions regarding the underlying level of evidence and strength of recommendations.…
Poster Investigating Impact of Dietary Patterns: Can Consistent Findings Between Controlled Trials and Observational Evidence Improve Confidence?
Rozga, Moloney, Handu
Background: Designs of studies examining dietary patterns (DPs) carry different limitations including short durations and conditions not reflective of the real world in controlled trials (CTs) and confounders associated with dietary choices and health outcomes in observational studies (OSs).…