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Displaying 21 - 40 of 261 records Index
Poster Agreement between systematic reviews (SRs) and clinical practice guidelines (CPGs) on drug treatment in acute stroke
2006 Dublin
José Martinez-Zapata, Urrutia, Gutierrez-Ibarluzea, Moniche, Ciapponi, Bonfill
Background: Clinical practice guidelines (CPGs) could improve clinical practice and should include systematic reviews (SRs) as their main ingredients in order to be evidence based.
Objectives: To assess the degree of concordance of the conclusions of all SRs available on acute ischaemic stroke…
Poster An assessment of the performance of meta-analytical methods for pooling intervention effects based on continuous data
2006 Dublin
McKenzie, Deeks, Green
Background: When pooling intervention effects calculated from continuous data, review authors will commonly encounter estimates of intervention effect calculated from a variety of methods, a small number of randomized controlled trials (RCTs) with some or all including few participants,…
Poster Applicability of Cochrane reviews in a developing country setting- a pilot study
2006 Dublin
Mathew, Mathew, Singh
Background: Cochrane reviews are the best resource for evidence concerning clinical interventions; however most reviews are generated by and for people in developed countries.
Objectives: To assess the applicability of Cochrane reviews in a developing country setting.
Methods: Respiratory…
Poster Approaches to interim analysis of randomized clinical trials in cancer: a survey from the Italian National Monitoring Centre for Clinical Trials
2006 Dublin
Floriani, Torri, Rotmensz, Albertazzi, Tomino, Martini, de Rosa, de Braud, Moja
Background: Several important questions have been raised about the decision to stop a randomized trial early and on what basis to reach such a decision, particularly in treatment trials in chronic life-threatening diseases, like cancer. A range of formal statistical approaches can be used as a…
Oral Appropriateness of asymmetry tests for publication bias in meta-analysis: large-scale survey
2006 Dublin
Ioannidis, Trikalinos
Background: Statistical tests for funnel plot asymmetry are common in meta-analyses. Inappropriate application could generate misleading inferences.
Objectives: To evaluate how often asymmetry tests would be appropriate to apply in meta-analyses.
Methods: We evaluated all 6,873 non-identical meta…
Oral Are harms reported in abstracts of trial results from conference proceedings?
2006 Dublin
Scherer
Background: The primary objective of most systematic reviews is to report the effectiveness of the treatment intervention, including both efficacy and harms of the test intervention. It is not known how often reports of harms are included in abstracts describing trial results and presented at…
Poster Are we listening to QUOROM (Quality of Reporting of Meta-analyses)? An evaluation of journal-published oral health systematic reviews
2006 Dublin
Turley, Sander
Background: The Oral Health Specialist Library, a specialist website within the National Library for Health, methodically identifies, appraises and summarises research to provide rapid access to the best available evidence for use in oral health care. During assessment of oral health systematic…
Workshop Assessing healthcare interventions along the complex-simple continuum
2006 Dublin
Lewin, Glenton, Oxman
Objectives: To consider how the complexity of healthcare interventions might be assessed, focusing on a newly developed complexity grading tool.
Summary: Healthcare interventions fall along a spectrum from simple to highly complex. There is growing interest in the design and evaluation of so-…
Poster Assessing healthcare interventions along the complex-simple continuum: a proposal
2006 Dublin
Lewin, Oxman, Glenton
Background: Healthcare interventions fall along a spectrum from simple to highly complex. There is growing interest in the design and evaluation of so-called complex interventions, but little work has been conducted on how intervention complexity might be conceptualised or assessed.
Objectives: To…
Poster Assessment of methodological quality of clinimetric reviews: a systematic review
2006 Dublin
Mokkink, Terwee, Stratford, Alonso, Patrick, Riphagen, Bouter, De Vet
Background: A tool for selecting the best health status measurement instrument for research is a systematic review of measurement instruments, i.e. a clinimetric review. In a clinimetric review all different measurement instruments on a well-defined concept are described and evaluated.
Objectives…
Poster Assessment of the methodological quality of reporting of randomized trials in Iranian healthcare journals
2006 Dublin
Nasser, Al-Hajeri, Eisinga, Fedorowicz
Background: Careful design, conduct and analysis of a randomized controlled trial minimizes bias so that any differences observed between participants may, apart from random error, be attributed to the intervention. The assessment of methodological quality of trials is intertwined with the quality…
Poster Authenticity investigation and quality assessment of claimed randomized controlled trials on upper respiratory infection
2006 Dublin
Zhang, Wu, Xie, Yan
Background: Lots of 'claimed' randomized controlled trials (RCTs) on upper respiratory infection have been published in China and always with positive results. However, their quality is unknown.
Objectives: To identify the quantity of 'true' RCTs in 'claimed' RCTs and…
Poster Author affiliation influences the presentation of benefits and harms of mammography screening in scientific articles
2006 Dublin
Juhl Jørgensen
Background: Conflicts of interest can influence the evaluation and presentation of scientific results. There are professional, political, and financial conflicts of interest related to the promotion of mammography screening.
Objectives: To examine if author affiliation influences the presentation…
Poster Barriers to meta-analysis of time-to-event data: a case study
2006 Dublin
Hind
Background: Methods for the meta-analysis of time-to-event data using summary statistics have been available since the late 1990s and their use is becoming more common in systematic reviews. However, several facets of time-to-event data present problems to the reviewer, particularly in older, more…
Workshop Basics of meta-analysis
2006 Dublin
Lewis, Hopewell
Objectives: To provide review authors with the knowledge to do a basic meta-analysis.
Summary: This workshop will cover the basic methods of meta-analysis available to review authors using RevMan software. The differences between methods will be discussed, and advice given on which should be used…
Poster Between-the-eyes adverse drug reactions: anecdotes as evidential gold standards
2006 Dublin
Aronson, Hauben
Background: Many adverse drug reactions are first reported anecdotally and therefore require formal verification, although a minority are actually verified1. We propose that there are adverse drug reactions (we call them between-the-eyes reactions) that are so convincing that only one anecdotal…
Poster Bibliographic analysis of the Cochrane Effective Practice and Organisation of Care Group's reviews
2006 Dublin
McGowan, Sampson, Salzwedel, Daniel, Grimshaw
Background: Scopus is a new abstract and citation database produced by Elsevier Science. Its data sources include MEDLINE, EMBASE, open access sources, scientific websites and grey literature. Scopus indexes Cochrane reviews, which include reviews from the Cochrane Effective Practice and…
Poster CENTRAL HELLIS: searching for the lost trials of South-East Asia
2006 Dublin
Ashworth, Adams
Background: Part of the EU-Practihc project (Pragmatic Randomized Controlled Trials in Health Care http://www.practihc.org) was to identify and survey randomized trials originating from low-and middle-income countries. As part of this initiative bibliographic databases other than the Cochrane…
Poster Caveats in the meta-analysis of continuous data: a simulation study
2006 Dublin
Banerjee, Wells
Objectives: To determine if results of meta-analyses with continuous data are different if final value (treatment end value) only, change value (treatment end value - baseline value) only or a combination of these are used.
Methods: Baseline and final values were simulated by generating bivariate…
Poster Centralised Cochrane review updating: the experience of the Cochrane Pregnancy and Childbirth Group
2006 Dublin
Smyth, Hampson, Henderson, Atherton, Neilson
Background: Cochrane reviews aim to provide healthcare professionals, consumers, and policy makers with the most up-to-date available evidence on the effects of healthcare interventions. Maintaining reviews is a core responsibility for review authors and review groups and it is recommended reviews…