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Displaying 581 - 600 of 954 records Index

Poster Network meta-analyses in clinical practice guidelines: A cross-sectional survey

2017 Cape Town [Global Evidence Summit]
Yan, Yang, Yao
Background: The development of clinical practice guidelines (CPGs) should base on systematic reviews. Network meta-analyses (NMAs) are useful in CPGs when there is no evidence directly comparing interventions of interest (indirect treatment comparison; ITC), or when combining direct and indirect…

Oral Network meta-analysis of complex interventions: accounting for component effects and control group risk

2017 Cape Town [Global Evidence Summit]
Freeman, Scott, Powell, Johnston, Sutton, Cooper
Background: In many medical areas treatment interventions consist of multiple components. In 2009 Welton et al. (1) proposed 4 increasingly complex network meta-analysis models for assessing component effects of complex interventions. The additive-effects model allows a separate effect for each…

Special Session New approaches to enhance evidence use through continued technical support and collaboration with policy makers and senior officials

2017 Cape Town [Global Evidence Summit]
Sherry, Brandes
Objectives: This special session aims: to describe novel approaches for evidence translation and evidence use for capacity building at local, national and international levels; to solicit stakeholder feedback on newly developed approaches; and;,to discuss the value of developing implementation…

Workshop New ways to bring people together to create guidelines and systematic reviews: TaskExchange and Cochrane Crowd

2017 Cape Town [Global Evidence Summit]
Turner, Noel-Storr, Mavergames
Objectives:The session will introduce the newest versions of TaskExchange and Cochrane Crowd, describe their aims, progress and future plans; and how both platforms can support high-quality guideline and systematic review development. Description: Two new platforms, TaskExchange and Cochrane Crowd…

Oral Next Generation Evidence System for Maternal and Child Health Evidence: A report on the Cochrane-Gates Foundation project

2017 Cape Town [Global Evidence Summit]
Beecher, Mavergames, Becker, Noel-Storr, Ali, Bridges, Friesen, Hampson, Jurado, Ovelman, Thomas, Weiss, Woods
Background: In September 2016 Cochrane received a grant from the Bill and Melinda Gates Foundation to accelerate our development of a 'next generation evidence system' in the areas of maternal and child health in support of the Gates Foundation’s ‘Healthy Birth Growth and Development…

Poster Non-communicable diseases in the Eastern Mediterranean Region (EMR): An overview of reviews

2017 Cape Town [Global Evidence Summit]
Akkawi, Noubani, Jamali, Lotfi, Mehio Sibai
Background: In the Eastern Mediterranean Region (EMR), more than 1.7 million deaths occur yearly from the four main types of non-communicable diseases (NCDs): cardiovascular diseases, cancer, diabetes and chronic respiratory diseases. The research productivity and quality in the EMR is low with…

Oral Novel approaches to conducting overviews of reviews: Lessons from four overviews of health systems interventions

2017 Cape Town [Global Evidence Summit]
Lewin, Oxman, Ciapponi, Herrera, Opiyo, Pantoja, Paulsen, Rada, Wiysonge
Background: Overviews of the findings of systematic reviews of health systems interventions can help policy makers and other stakeholders to identify strategies for strengthening health systems. Methods for conducting such overviews are still evolving. Objectives: 1) To examine the strengths and…

Poster Objective impairments of gait and balance in adults living with HIV-1 infection: A systematic review and meta-analysis of observational studies

2017 Cape Town [Global Evidence Summit]
Berner, Morris, Baumeister, Louw
Background: Gait and balance deficits are reported in people with living with HIV (PLHIV) and are associated with reduced quality of life. Current research suggests an increased fall-incidence in this population, with fall rates among middle-aged PLHIV approximating that in seronegative elderly…

Oral Obtaining absolute effect estimates to facilitate shared decision making in the context of multiple-treatment comparisons

2017 Cape Town [Global Evidence Summit]
Spineli, Brignardello-Petersen, Heen, Achille, Brandt, Guyatt, Vandvik, Agoritsas
Background: When engaging in shared decision making (SDM) clinicians and patients need to discuss the benefits and harms of available treatment options. To avoid framing bias, decision aids should present the evidence as absolute estimates of effect, but there is no established methodology to…

Poster Off-label use of medicines: Considerations for National Institute for Health and Care Excellence guideline development

2017 Cape Town [Global Evidence Summit]
Thornton, Hulme
Background: All medicines prescribed in the UK should have a ‘licence’ granted by MHRA, i.e. medicine is effective, clinical safety has been assessed and manufacturing process produces a quality product. When licensed medicines are used outside of this marketing authorisation this would be ‘off-…

Oral Old guidelines, the SIGN decision to remove guidelines at 10 years

2017 Cape Town [Global Evidence Summit]
Kinsella, James
Background: Guideline development is time consuming and costly. Once published, guidelines may become rapidly outdated. SIGN has adopted a variety of approaches to ensuring that guidelines remain up to date and relevant. Despite this, very old guidelines remain a concern because the content could…

Poster On the overlap and contrasts between ICHOM, assessment outcomes and quality indicators

2017 Cape Town [Global Evidence Summit]
Verstijnen, Koopman, De Boer, Kleijnen
Background: The Dutch National Health Care Institute (NHCI) assesses evidence on the effectiveness of interventions for the purpose of reimbursement decisions. It also hosts the national register of guidelines containing medical guidelines together with their relevant quality indicators. The choice…

Poster Optimising rapid-review production: New search filter to identify simultaneously systematic reviews, guidelines, health-technology assessments and RCTs in PubMed

2017 Cape Town [Global Evidence Summit]
Comandé, Ciapponi, Bardach, García-Martí , Glujovsky, Alcaraz, Pichon-Riviere, Augustovski
Background: Rapid reviews have emerged as an efficient approach to synthesising evidence using simplified processes. Filters capable of capturing systematic reviews, guidelines, RCTs and health-technology assessments (HTAs) at once could improve the efficiency of literature search. PubMed lacks a…

Oral Optimising search filters for active literature surveillance: a concordance study

2017 Cape Town [Global Evidence Summit]
Alper, Hertzman-Miller, Iorio
Background: A major challenge in keeping clinical guidelines and structured recommendations current is to identify new, relevant evidence in a resource-efficient way. Prior research found that sensitivity (minimising the number of missed relevant references) or efficiency (low number needed to read…

Poster Oral administration of Chinese herbal medicine during gestation period for preventing hemolytic disease of the newborn due to ABO incompatibility: A systematic review of randomised-controlled trials

2017 Cape Town [Global Evidence Summit]
Cao, Wu, Han, Caldwell, Liu
Background: About 85.3% of hemolytic disease of newborn (HDN) is caused by maternal-fetal ABO blood group incompatibility, however, there is currently no recommended 'best' therapy for ABO incompatibility during gestation. Objectives: To systematically assess the safety and…

Oral Outcome choice and potential loss of valuable information - an example from a Cochrane Eyes and Vision systematic review

2017 Cape Town [Global Evidence Summit]
Clearfield, Money, Saldanha, Chuck, Lindsley
Background: Outcomes selected for systematic reviews (SRs) should address clinical uncertainties to help make treatment decisions. However, when reviewers select outcomes by specifying the outcome’s 5 elements (domain, measurement, method of aggregation, metric, and time point) these may not match…

Poster Outcome measures for keloids assessment in clinical trials

2017 Cape Town [Global Evidence Summit]
Morales-Sánchez, Peralta-Pedrero, Olguín-García, Jurado_Santa Cruz
Background: Multiple scoring systems to assess scars have been developed and are been used to measure the efficacy of the treatments for scar. There is no synthesis about those used in keloids. Objective: To summarise and critically appraise the evidence of the reported outcomes in clinical…

Poster Outcome switching in clinical trials – an analysis of the German Clinical Trials Register

2017 Cape Town [Global Evidence Summit]
Kunzweiler
Background: Switching of outcomes in trials is a well-known problem in clinical research. It has been observed that clinical trial reports are often not identical with the protocol or registry entry of the study, especially with regard to the reporting of the outcomes. This problem leads to a lack…

Poster Outcomes of a clinical guideline for implementation of Kangaroo Care with premature infants in a Neonatal Intensive Care Unit, Maharaj Nakorn ChiangMai Hospital

2017 Cape Town [Global Evidence Summit]
Papana
Background:Preterm infants in neonatal intensive care unit are treated and exposed to several stressful interventions. The separation between these infants and their mothers is a major stressor. Kangaroo Mother Care (KMC) has proved beneficial for preterm infants and their mothers. Objectives:…

Poster Outcomes relevant for insurance medicine - an evaluation of Cochrane reviews and new initiative

2017 Cape Town [Global Evidence Summit]
Hoving, Weida, de Boer, Vogel, Schaafsma, Kunz
Background: Cochrane Insurance Medicine (CIM) promotes the use of evidence regarding sick leave certification, disability evaluation, prognosis of claim duration, treatment of disabling conditions, and return to work (RtW) interventions to inform decision‐making in a domain of high importance to…