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Oral Affiliational bias in arguments regarding the use of systematic reviews in health policy decision making
2010 Keystone
Odierna, Gibson, Bero
Background: Systematic reviews inform public- and private-sector drug coverage and other health policy decisions. Arguments for and against this use of systematic reviews may be related to authors’ affiliations, income sources, and ideological backgrounds. For example, when meta-analyses concluded…
Poster Affiliational bias in arguments regarding the use of systematic reviews in health policy decision making
2010 Keystone
Odierna, Gibson, Bero
Background: Systematic reviews inform public- and private-sector drug coverage and other health policy decisions. Arguments for and against this use of systematic reviews may be related to authors affiliations, income sources, and ideological backgrounds. For example, when meta-analyses concluded…
Poster An Evaluative system and Effects Research of Problem Based Learning
2010 Keystone
Jin, Banghua, Mingheng, Jinnan, Youping
Background: More and more medical schools in China start to use problem-based learning(PBL) throughout their education, therefore, the evaluation on the effective- ness of PBL becomes extremely improtant. Objective: To establish an assessment system of PBL curriculum which is a suitable for Chinese…
Poster An innovative box plot for assessing data trends associated with selective dissemination of evidence
2010 Keystone
Bax, Wang, Satoh, Moons
Background: Box plots are widely used in exploratory data analyses of data from primary research. However, they are commonly not used in meta-analyses because of their inherent inability to integrate the relative weights of studies. Methods: We developed a horizontal box plot that uses the central…
Oral An international register of ongoing systematic reviews
2010 Keystone
Booth, Clarke, Ghersi, Moher, Petticrew, Stewart
Background: Support is growing for the prospective registration of protocols for systematic reviews. As for clinical trials, registration could be an important means of combating publication and selective outcome reporting biases. Registration could also help avoid unnecessary duplication;…
Poster Analysis and assessment of systematic reviews of Chinese herbal medicine published in Cochrane Library
2010 Keystone
Hu, Shang, Zhang
Objective: To analyze and assess the systematic reviews of Chinese herbal medicine published in Cochrane Library. Methods: We searched all reviews of Chinese herbal medicine in Issue 1, 2010 of the Cochrane Database of Systematic Reviews. For each review, we collected information of the title of…
Poster Analysis of conflicting results of 2 non-randomized controlled trials
2010 Keystone
Peinemann, Kulig
Background: In the framework of a systematic review on patients with rhabdomyosarcoma with vs. without autologous stem cell transplantation, we identified a total of 4 non-randomized controlled studies. Two studies reported statistically significant, yet contradictory, estimates of the overall…
Oral Answering clinical questions at the point of care using Cochrane evidence
2010 Keystone
Urquhart, MacLehose
Background: Many summaries and commentaries of Cochrane Reviews are available, but what doctors and other healthcare professionals need at the point of care (before/during/after a patient encounter) is answers to clinical questions. Objectives: To develop new Cochrane content—the ‘‘Cochrane…
Poster Answering questions put forward by local musculoskeletal pain clinicians in the UK
2010 Keystone
Jordan, Stevenson, Lewis, van-der-Windt
Background: A multidisciplinary group of clinicians with academic partners in North-west England was established to develop critically appraised topics (CATs) addressing questions on musculoskeletal care generated in practice. CATs are disseminated locally to healthcare practitioners, managers and…
Poster Applicability of the Newcastle-Ottawa Scale (NOS) for rating quality of cohort studies: using studies regarding the predictors of returning to work after traumatic limb injuries for example
2010 Keystone
Hou, Lin, Wei, Hsieh, Lu, Chiu, Ni
Background: Systematic review and meta-analysis of observational studies is getting more and more common as systematic review and meta-analysis of controlled clinical trials in order to answer the etiologic or effectiveness questions from the explosion information of scientific literatures. Cohort…
Poster Application of the Knowledge to Action cycle in a Public Health Setting
2010 Keystone
Francis, Baker
Background: The Knowledge to Action loop is a conceptual framework used to describe the movement of knowledge into action. It integrates the functions of knowledge creation, with that of knowledge application. This model was used as the basis for a 3-day advanced evidence-based practice course for…
Oral Applying the GRADE tool in systematic reviews: inter-rater reliability and sources of discrepancy
2010 Keystone
Hartling, Fernandes, Vandermeer, Dryden
Background: GRADE was developed to address shortcomings of tools to assess quality of a body of evidence. This is a key step in making recommendations to inform decision-making. While much has been published around GRADE, there are few empirical and systematic evaluations. Our objective was to…
Poster Are all Cochrane reviews born equal? Methodological quality across different Review Groups
2010 Keystone
Pantoja, Moreno, Soto
Background: High quality systematic reviews are increasingly recognized as providing the best evidence to inform healthcare decisions at different levels. The quality of a review and then the confidence that a decision maker puts on its findings depends on the extension to which its design will…
Poster Are systematic reviews original research? - survey of editors of core clinical journals
2010 Keystone
Herrle, Meerpohl, Reinders, von-Elm
Background: Research synthesis has growing impact in evidencebased
medicine and knowledge translation. Systematic reviews (SR) represent a cornerstone of research synthesis and require scientific rigour. Nevertheless, SR are often criticised as secondary research and not granted the status of…
Poster Are test treat trials as rare as suspected? A capture-recapture estimate of numbers published
2010 Keystone
Ferrante-di-Ruffano, Davenport, Eisinga, Bayliss, Fry-Smith, Hyde, Deeks
Background: The ultimate aim of diagnostic test evaluation is to determine which tests have the most favourable impact on patient health. Randomised controlled trials are the methodological gold-standard for evaluating these questions, however it is a common anecdote that such publications are rare…
Poster Are you listening? Podcasts from The Cochrane Library; a review
2010 Keystone
Simmonds, Clarke, Mavergames
Background: Podcasts from The Cochrane Library were first launched in January 2008. Since then, there has been an increase in acceptance from authors to record podcasts, but also a huge increase in usage for Cochrane podcasts. Now, with monthly publication, and fewer podcasts published, but more…
Oral Assessing the effect of adjusting for funnel plot asymmetry in networks of interventions
2010 Keystone
Salanti
Background: Several methods for testing and adjusting for funnel plot asymmetry can provide useful resultswhen applied to a large set of fairly homogeneous trials [1]. As Cochrane reviews typically include few or heterogeneous studies, methods to adjust for small study effects are not often used.…
Poster Assessing the quality of the evidence for preterm labor tocolysis trials
2010 Keystone
Haas, Kirkpatrick, Jury, Caldwell
Background: Tocolytic therapy to stop preterm labor is an important intervention in obstetrics. Despite themany randomized controlled trials (RCTs) of different interventions, no comprehensive updated summary evaluation of the evidence has been undertaken. Objective: To assess the quality of…
Oral Assessment of risk of bias in prognostic studies
2010 Keystone
Wolf, Westwood, Scheibler, Schroeer-Guenther, Janßen, Kleijnen
Background: Prognostic studies aim to assess the ability of diagnostic tests or clinical observations to predict future events, or to evaluate associations of risk factors and health outcomes in populations of patients [1]. Prognostic research has to date received much less attention than research…
Oral Assessment of trial similarity and evidence consistency for indirect comparisons: preliminary results
2010 Keystone
Xiong, Parekh-Bhurke, Kong-Loke, Song
Background: Adjusted indirect comparisons (AIC) are increasingly used for evaluating healthcare interventions in situations where there is limited head-to-head trial evidence. However methods for assessing validity of AIC have not been systematically developed and tested. Objectives: To investigate…