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Oral An empirical assessment of bivariate methods for meta-analysis of test performance
2012 Auckland
Dahabreh, Trikalinos, Lau, Schmid
Background: Meta-analysis of diagnostic test accuracy studies must account for correlation between sensitivity and specificity. Summary receiver operating characteristic (SROC) curves and bivariate models have become methods of choice. However, different forms of these techniques exist and methods…
Workshop An introduction to systematic reviews of prognosis and prognostic factors
2012 Auckland
Moons, Williams, Ridley, Hayden, Riley, Altman, Woolfenden
Objectives:
This workshop will introduce participants to systematic reviews of prognosis and prognostic studies. We will discuss challenges with this type of review and help participants formulate a prognostic review question. We will introduce methods and resources for conducting a systematic…
Poster Application of the GRADE methodology to Cochrane diagnostic test accuracy reviews
2012 Auckland
Gopalakrishna, Mustafa, Davenport, Scholten, Hyde, Brozek, Schünemann, Langendam, Leeflang, Bossuyt
Background: The GRADE criteria for rating evidence can also be used for evaluating the results of diagnostic accuracy studies, but more experience is needed.
Objectives: We applied the GRADE methodology to published Cochrane diagnostic test accuracy reviews (DTAR) with the aim of better…
Poster Applying sex and gender analysis to systematic reviews: development of a new knowledge translation tool
2012 Auckland
Puil, Doull, Tudiver, Bascoe, Welch, Runnels, Shea, O’Neill
Background: The safety and effectiveness of health interventions can differ within and among populations of men and women for many reasons including issues of sex and gender. Despite growing recognition that the application of sex/gender analysis is important for discerning for whom an intervention…
Oral Approaches to prioritisation: the Cochrane Airways Group experience
2012 Auckland
Welsh, Karner, Stovold, Cates
Background: We have traditionally registered review titles from individuals with a passion for their subject and sufficient skills and support to complete their review. While this has produced a breadth of topics that we are proud of, we have a duty to maximise the utility of our review portfolio…
Poster Approaches to risk of bias assessments in non-Cochrane reviews
2012 Auckland
Hartling, Sumamo Schellenberg, Shulhan, Dryden
Background: The Cochrane Collaboration released recommendations for the conduct of SRs in 2011. They recommend using the Cochrane Risk of Bias (ROB) tool for assessing risk of bias in randomized controlled trials (RCT) but lack specific guidance for non-randomized studies.
Objectives: (1)…
Poster Are Australian Human Research Ethics Committees effectively promoting prospective trial registration?
2012 Auckland
Tai, Ooi, Hunter, Ko, Askie
Background: Clause 3.3.12 of the Australian National Statement on Ethical Conduct in Human Research 2007 (The Statement) states: ‘Before beginning the clinical phase of the research, researchers should register clinical trials in a publicly accessible register.’
Objectives: To survey Australian…
Poster Are volunteers authoring Cochrane reviews? A brief investigation.
2012 Auckland
Burton, Chapman
Background: The Cochrane Collaboration encourages wide participation in its work and seeks to reduce barriers to participation by a diverse range of individuals. Contributors include volunteers and paid staff. To what extent are Cochrane reviews authored by ‘volunteers’ rather than individuals who…
Oral Assessing the impact of missing participant data for continuous outcomes in systematic reviews on risk of bias
2012 Auckland
Ebrahim, Mustafa, Heels-Ansdell, Sun, Akl, Walter, Guyatt
Background: No methods directly address the impact of missing participant data for continuous outcomes in systematic reviews on risk of bias.
Objectives: To develop approaches for addressing missing participant data for continuous outcomes in systematic reviews.
Methods: We conducted a…
Poster Assessing the number, characteristics and quality of randomized controlled trials conducted in Japan
2012 Auckland
Yoneoka, Ota, Hisashige, Miyamoto, Nomura, Segawa, Kanda, Shibuya
Background: The randomized controlled trial (RCT) is the most powerful research tool for evaluating health technologies. The number of RCT is rapidly increasing internationally. Despite the rapid increase in research in Japan, little is known about comprehensive information of RCTs conducted there…
Poster Assessment of methodological quality of systematic reviews published in the Cochrane Library about physical activity for chronic noncommunicable diseases
2012 Auckland
Carvalho, Grande, Silva, Martimbianco, Puga, Melnik, Atallah
Background: Chronic Noncommunicable Diseases (NCDs) is the leading cause of mortality worldwide (36 millions of deaths or 63% of all deaths). The number of systematic reviews (SRs) about physical activity for treating and preventing NCDs has increased, and there is a need to assess the…
Poster Assessment of research quality in major infertility journals
2012 Auckland
Glujovsky, Boggino, Coscia, Riestra, Comande, Sueldo, Ciapponi
Background: Systematic reviews (SR) and randomised controlled trials (RCT) are at the top of the pyramid in quality research. But little is known about the number and quality of SRs and RCTs published in peer-reviewed journals.
Objectives: To evaluate the quality of research of published…
Poster Bayesian hierarchical models for complex meta-analyses using MCMCglmm in R
2012 Auckland
Nakagawa, Hadfield
Background: Available easy-to-use software packages for metaanalysis do not cope with multiple nested or correlated structures in data (e.g. subjects, hospitals, regions, countries) whereas more flexible and fully capable packages such as WinBUGS require detailed coding.
Objectives: We provide…
Oral Best practices in patient and stakeholder engagement
2012 Auckland
Curtis, Slaughter-Mason, Thielke, Gordon, Pettinari, Ryan, Church, King
Background: Patient involvement in health services and clinical research is emerging as a priority in the US. Congress passed legislation in 2010 establishing an independent Patient Centered Outcomes Research Institute (PCORI). PCORI is developing guidance for involving patients in its research to…
Poster Bias associated with selective crossover in randomised controlled trials
2012 Auckland
D’Amico, Petracci, Balduzzi, Moja, Miglio
Background: Recently, several randomised controlled trials (RCTs) in which unplanned patient crossover to the experimental arm occurs during the study, have been published in the literature (1, 2). This phenomenon is referred to as selective crossover and is increasingly common.
Objectives: To…
Oral Blinding in randomised controlled trials of surgical procedures in children: who, when and how
2012 Auckland
McGee, Hua, Craig, Webster
Background: Blinding is the process by which people are kept unaware of trial intervention allocations after randomisation. It is designed to prevent performance bias and detection bias. Conducting trials in surgery and in paediatrics is acknowledged as particularly challenging. By studying how…
Workshop Building capacity with Cochrane webinars: tips and tricks for presenters
2012 Auckland
Ueffing, Cuervo, Cumpston, Stevens
Objectives:
• To introduce participants to a virtual platform used for Cochrane webinars;
• To build capacity amongst Cochrane contributors to prepare and present successful webinars; and
• To share strategies for engaging webinar participants.
Description:
Through support from…
Poster Can American Indian and Alaska Native populations ever have a sufficient research base for best practices?
2012 Auckland
Seals, Marchionda
Background: Cancer disparities continue to increase for some small populations and current programs have little guidance. Only one Cochrane review exists relevant for United States (US) Indigenous populations such as American Indians and Alaska Natives (AIAN). Even the existing review notes the…
Poster Can English-speaking reviewers correctly identify foreignlanguage articles that meet eligibility criteria for a systematic review of management for fibromyalgia?
2012 Auckland
Busse, Ngo, Torrance, Kirmayr, Avrahami, Riva, Ebrahim, Struijs, Malik, Bruno, Brunarski, Burnie, LeBlanc, Connell, Coomes, Steenstra, Montori, Guyatt
Background: Systematic reviews endeavor to capture all publications that meet pre-defined eligibility criteria. Non-English studies may present resource challenges in meeting this goal. If English-speaking reviewers could differentiate eligible from ineligible foreign language publications it would…
Poster Can data extraction from figures perform a meta-analysis?
2012 Auckland
Silva, Carvalho, Grande, Martimbianco, Riera, Atallah
Background: Systematic reviews (SR) with the statistical methods of meta-analysis represent the highest level on the evidence to make decision. Extracting data can be a problem when randomized clinical trials (RCT) publish figures as the only source of outcome data. Thus, none included RCTs in the…