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Displaying 5901 - 5920 of 10301 records Index

Poster Handling missing data in a randomized controlled trial: example from an Attention Deficit/Hyperactive Disorder (ADHD) trial

2014 Hyderabad
Toghrayee
Background: Missing data is a common problem encountered in clinical trials. Researchers intending to analyze their data using Intention-to-treat principles commonly impute the missing data to achieve balanced data before analysis using analysis of variance (ANOVA) methods. A lesser known but…

Poster Handling trial participants with missing dichotomous outcome data when conducting a meta-analysis: a methodological survey of proposed approaches

2014 Hyderabad
Akl, Kahale, Agoritsas, Brignardello Petersen, Busse, Carrasco, Ebrahim, Johnston, Neumann, Sola, Sun, Vandvik, Alonso-Coello, Guyatt
Background: Missing outcome data for trial participants represents a serious potential source of bias, particularly when associated with the likelihood of outcome events. Systematic review authors frequently deal with this problem when conducting meta-analyses. Objectives: To review the…

Workshop Harmonising Cochrane content in the CRS: moving towards a nimble global dataset

2014 Hyderabad
Noel-Storr, Foxlee, Dooley, Littlewood, Salzwedel
Objectives: The implementation of the Cochrane Register of Studies (CRS) saw the migration of 52 specialized registers into one bespoke application and has highlighted some significant variations in the content of common fields. The CRS provides an opportunity to standardize and harmonize certain…

Oral How can we accurately diagnose schizophrenia? Challenges in performing Cochrane diagnostic test accuracy reviews in schizophrenia

2014 Hyderabad
Maayan, Adams, Bergman, Davenport, Palaniyappan, Soares-Weiser
Background: Since the 1950's researchers have been trying to standardize the way schizophrenia is diagnosed. We recently completed six Cochrane Reviews assessing the accuracy of four checklists (First Rank Symptoms, OPCRIT+, K-SADS and CIDI), magnetic resonance imaging (MRI) and blood tests to…

Workshop How can we make Cochrane Reviews more readable?

2014 Hyderabad
Garner, MacLehose, Clark
Objectives: - To outline basic principles for effective writing. - To learn how to enhance the process of writing. - To practice effective writing skills. Description: This workshop will be useful to any Cochrane author, academic researcher, or individual writing newsletters or other…

Poster How do systematic review users and producers interpret the stability of review findings based on GRADE quality of evidence ratings?

2014 Hyderabad
Thaler, Sommer, Dobrescu, Swinson Evans, Lohr, Gartlehner
Background: The GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach uses information about study limitations, imprecision, inconsistency, indirectness, and publication bias to determine quality of evidence (QoE) and communicate the confidence that systematic…

Poster How do systematic reviews incorporate assessment of study quality into the synthesis of evidence? A methodological study

2014 Hyderabad
Katikireddi, Egan, Petticrew
Background: Recent research investigating methods used in systematic reviews (SRs) has found increasingly that critical appraisal of included studies is being performed. Critical appraisal constitutes an important input into the synthesis process as it allows reviewers to explore whether…

Poster How handling of missing data impacts trial results: a meta-epidemiological study

2014 Hyderabad
Døssing, Tarp, Furst, Gluud, Beyene, Brandt Hansen, Bliddal, Christensen
Background: In randomised clinical trials (RCTs) dropouts cause missing data [1] and the efficacy analyses may be conducted using imputation. Two common imputation methods are last observation carried forward (LOCF) and non-responder imputation (NRI). NRI is recommended and presents a…

Poster How has usage of full text Cochrane Reviews developed since 2011 and what are the factors that lead to an increase or decrease in usage?

2014 Hyderabad
Stewart
Background: Cochrane Reviews have been published by Wiley since 2002 and can be accessed via the Wiley Online Library platform. Approximately 3.5 billion people (half of the World’s population) have access to full text versions of Cochrane reviews. The majority of users access full text versions…

Poster How to appraise Individual Participant Data (IPD) meta-analysis in diagnostic and prognostic risk prediction research

2014 Hyderabad
Moons, Debray, Rovers, Riley, Reitsma
Background: The development and (external) validation of diagnostic and prognostic prediction models is an important aspect of contemporary epidemiological research. Unfortunately, many prediction models perform more poorly than anticipated when tested or applied in other individuals, and…

Poster How to choose the right journal for your systematic review

2014 Hyderabad
Betini, Volpato, El Dib
Background: Due to the importance of systematic reviews (SRs) as a source of decision making in health care, there is an increasing interest in the development of this type of study. The main reasons that authors seek to publish in higher impact factor journals are career advancement, grant…

Workshop How to create a matrix of evidence in Epistemonikos

2014 Hyderabad
Rada, Peña, Capurro, Neumann, Rivera, Valverde, Soto, Pérez
Objectives: To present a new tool, Epistemonikos (www.epistemonikos.org), that allows a dynamic matrix of evidence to be created in just a few minutes for all existing systematic reviews (and their included studies) for a specific PICO question. Description: Epistemonikos searches for…

Workshop How to develop brief economic commentaries for Cochrane intervention reviews

2014 Hyderabad
Vale
Objective: To provide training in the process of developing brief economic commentaries for inclusion in Cochrane intervention reviews. Description: Incorporating brief, evidence-informed economic commentaries into the Background and/or Discussion sections of Cochrane intervention reviews…

Workshop How to include economics in Cochrane Review Protocols. Part 1: background, objectives, outcome measures and types of studies

2014 Hyderabad
Vale
Objectives: Incorporating health economic evidence into Cochrane Reviews can facilitate decision making. It takes into account the costs and provide the international context within which previously published evidence can be interpreted and assessed as a preliminary to economic evaluation. This…

Workshop How to include economics in Cochrane Review Protocols. Part 2: searches, risk of bias and methodological quality, data collection and analysis

2014 Hyderabad
Vale
Objectives: Incorporating health economics evidence into Cochrane Reviews can facilitate decision making which takes account of costs and provide the international context within which previously published evidence can be interpreted and assessed as a preliminary to economic evaluation. This is…

Poster How was patient involvement in shared decision making covered in Cochrane review?

2014 Hyderabad
Jia, Zhang, Mao, Zhang
Background: Patient involvement has been emphasized by Cochrane Collaboration. However, little is known about the extent to which patient involvement in shared decision making has been covered in Cochrane systematic reviews (CSRs). Objectives: To investigate patient involvement in shared…

Poster Identifying information retrieval research for systematic reviews and other evidence syntheses beyond effectiveness reviews: Summarized Research in Information Retrieval (SuRe Info).

2014 Hyderabad
Lefebvre, Ormstad, Isojärvi, Chalon, Arber, Droste, Duffy, Glanville, Golder, Kaunelis, Lysdahl, Wood, Wright
Background: To date, Cochrane has focused primarily on publishing systematic reviews of the effectiveness of healthcare interventions and subsequently reviews of diagnostic test accuracy. Strategies to identify studies in these areas are well-described in the Cochrane Handbook. Cochrane is…

Workshop Identifying participants with missing outcome data in trials included in systematic reviews: challenges and suggested solutions

2014 Hyderabad
Akl, Kahale, Alonso, Ebrahim, Schuenemann, Guyatt
Objectives: To discuss the challenges with identifying participants with missing outcome data in trials included in systematic reviews, and suggestions for how to deal with those challenges. Description: The workshop will consist of the following: 1. A presentation on the current standards…

Poster Impact of infrastructure and direct funding on Cochrane reviews

2014 Hyderabad
Bailey, Hilton, Kenny
Background: The UK National Institute for Health Research (NIHR) contributes infrastructure funding of GBP 3 million to the Cochrane Review Groups (CRGs) and GBP 1.5 million of direct review funding, on an annual basis. “NIHR investment in systematic reviews means our health and care services…

Oral Impact of missing outcome data for participants in trials included in five Cochrane Reviews: an imputation study

2014 Hyderabad
Kahale, Ramly, Barba, Sperati, Terrenato, Ballout, Guyatt, Kahale, Schunemann
Background: We recently proposed a number of assumptions for handling missing participant data (MPD), and assessing the associated risk of bias. Objectives: To assess the impact of applying the proposed assumptions about the outcomes of participants with missing data on the statistically…